Rifampicin CAS:13292-46-1 99% Orange to red/brown powder
| Catalog Number | XD90358 |
| Product Name | Rifampicin |
| CAS | 13292-46-1 |
| Molecular Formula | C43H58N4O12 |
| Molecular Weight | 822.94 |
| Storage Details | -15 to -20 °C |
| Harmonized Tariff Code | 29419000 |
Product Specification
| pH | 4.5-6.5 |
| Assay | 99% |
| Appearance | Orange to red/brown powder |
| Loss on Drying | max 1.0% |
| Sulphated Ash | max 1.0% |
To investigate and compare the expression of recA and recX, components of the SOS pathway, following rifampicin treatment in drug-susceptible and MDR clinical strains of Mycobacterium tuberculosis.Strains (M. tuberculosis and Mycobacterium smegmatis) were subjected to rifampicin- and mitomycin-induced stress for 36 h followed by RNA extraction. recA and recX in the RNA extract were estimated using qRT-PCR.The MDR clinical strain induced faster (24 h) and higher (7-fold) levels of recA as compared with the drug-susceptible strain (36 h) in response to rifampicin. recX levels were found to rise with an increase in levels of recA; however, the levels were relatively higher than recA.Drug-susceptible and MDR strains have different kinetics of induction of DNA repair.© The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.
