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New weight-loss and lipid-lowering drug: Orlistat is a new type of weight-loss and lipid-lowering drug currently internationally recognized. With annual sales of US$538 million, orlistat currently occupies 80% of the global weight loss market, and the annual sales in Hong Kong, China alone reach US$80 million. It is currently the only OTC weight loss drug in the world. More than 40,000,000 people around the world have taken it and successfully lost weight. It is currently the best-selling weight loss product. It is effective for weight loss. Orlistat is a potent and long-acting specific gastrointestinal lipase inhibitor. By directly blocking the body's absorption of fat in food, once the intake of calories and fat is less than consumption, Body fat is naturally reduced, so as to achieve the purpose of weight loss. It is safe to lose weight, the active ingredients do not enter the blood circulation, and do not act on the central nervous system.

Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor, white or off-white powder at room temperature, insoluble in water, soluble in chloroform, and easily soluble in ethanol. The active serine sites of gastric lipase and pancreatic lipase form covalent bonds to inactivate the enzymes. The fat in food cannot be decomposed into free fatty acids and monoacylglycerols, so fat cannot be absorbed and utilized, thereby reducing the body's calorie intake and controlling body weight. This medicine does not require systemic absorption to work. At usual doses, the absorption of fat can be inhibited by 30%. It is rarely absorbed after oral administration, and can be inactivated by metabolism in the intestinal tract. The metabolic site is in the wall of the gastrointestinal tract, and the elimination half-life is about 14 to 19 hours. About 97% of this product is excreted with feces, of which 83% is excreted in its original form.

It can be used clinically in obesity and hyperlipidemia. Under normal circumstances, a dose of 120 mg can be taken orally, three times a day, with meals or 1 hour after meals. Weight can start to drop after 2 weeks of taking the drug. It can be taken continuously for 6 to 12 months. If the dose is increased to more than 400 mg per day, its effect will no longer be enhanced.