Neomycin Sulfate Cas: 1405-10-3
| Catalog Number | XD91890 |
| Product Name | Neomycin Sulfate |
| CAS | 1405-10-3 |
| Molecular Formula | C23H48N6O17S |
| Molecular Weight | 712.72 |
| Storage Details | 2-8°C |
| Harmonized Tariff Code | 29419000 |
Product Specification
| Appearance | White powder |
| Assay | 99% min |
| Melting point | >187°C (dec.) |
| alpha | D20 +54° (c = 2 in H2O) |
| refractive index | 56 ° (C=10, H2O) |
| Fp | 56℃ |
| solubility | H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
| PH | 5.0-7.5 (50g/l, H2O, 20℃) |
| Water Solubility | Soluble in water |
| Stability | Stable. Incompatible with strong oxidizing agents. |
NEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. NEOMYCIN SULFATE has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.
NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.
Neomycin sulfate is an antibiotic (can be used effectively against most bacteria that cause skin, eye and outer ear infections); broad-spectrum antibiotic in topical creams, powders, ointments, eye and ear drops; systemic antibiotic and growth promotor in veterinary use.
