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Chromium picolinate, a complex of trivalent chromium and picolinic acid, is better absorbed (2-5%) than dietary chromium.It is widely included in dietary supplements, espe-cially in multivitamin, multimineral products. These supplements are usu-ally available in capsule or tablet form.
Typical amounts of chromium picolinate used in multivitamin,multimineral dietary supplements range from 50 to 400 uglday. Specialtydietary supplements may contain much more chromium picolinate and mayinclude other forms of both chromium and picolinate.Chromium picolinateis also readily available in single-ingredient preparations or in combinationwith a few ingredients.
Chromium picolinate has been used successfully to control blood cholesterol and blood glucose levels. It also promotes the loss of fat and an increase in lean muscle tissue.Studies show it may increase longevity and help to fight osteoporosis.
Chromium picolinate (CrPic) is taken as the supplement or alternative medicine for type 2 diabetes. Experimental evidence has indicated CrPic boost glucose uptake via activating P38 MAPK. Chromium is thought to be able to enhance the action of insulin, thereby increasing insulin sensitivity in type 2 diabetes patients.

Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.