Uridine-5′-diphosphoglucuronic acid trisodium salt CAS:63700-19-6 White powder
| Catalog Number | XD90382 |
| Product Name | Uridine-5'-diphosphoglucuronic acid trisodium salt |
| CAS | 63700-19-6 |
| Molecular Formula | C15H19N2O18P2Na3 |
| Molecular Weight | 646.20 |
| Storage Details | < -4 °C |
Product Specification
| Assay | 99% |
| Appearance | White powder |
The present study aims to investigate the influence of irinotecan's toxicity by the biotransformation of glucoaurantio-obtusin to aurantio-obtusin. Intraperitoneal administration (i.p.) of 100 mg/kg aurantio-obtusin significantly increased the toxicity of irinotecan, but the i.p. administration of 100 mg/kg glucoaurantio-obtusin showed negligible influence towards irinotecan's toxicity. Furthermore, the mechanism was explained through determining the inhibition potential of glucoaurantio-obtusin and aurantio-obtusin towards the glucuronidation metabolism of SN-38 that has been regarded to be the major active product responsible for the toxicity of irinotecan. The results showed that aurantio-obtusin exhibited strong competitive inhibition towards the glucuronidation of SN-38, but negligible inhibition potential of glucoaurantio-obtusin towards SN-38 glucuronidation was observed. These results showed that biotransformation of glucoaurantio-obtusin towards aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation.
