China Online Exporter Pharmaceutical Intermediates - 2-Amino-3-(4-hydroxyphenyl)propanoic acid Cas: 556-03-6 99% Crystalline – XD BIOCHEM Manufacturer and Supplier

Online Exporter Pharmaceutical Intermediates - 2-Amino-3-(4-hydroxyphenyl)propanoic acid Cas: 556-03-6 99% Crystalline – XD BIOCHEM

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Online Exporter Pharmaceutical Intermediates - 2-Amino-3-(4-hydroxyphenyl)propanoic acid Cas: 556-03-6 99% Crystalline – XD BIOCHEM Detail:

Catalog Number	XD90297
Product Name	2-Amino-3-(4-hydroxyphenyl)propanoic acid
CAS	556-03-6
Molecular Formula	C9H11NO3
Molecular Weight	181.18854
Storage Details	Room temperature
Harmonized Tariff Code	29225000

Product Specification

Assay	99%
Appearance	Crystalline

Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models of Parkinson’s disease (PD). In this study, we assessed the neuroprotective effect of CDNF delivered with a recombinant adeno-associated viral (AAV) serotype 2 vector in a rat 6-hydroxydopamine (6-OHDA) model of PD. AAV2 vectors encoding CDNF, glial cell line-derived neurotrophic factor (GDNF), or green fluorescent protein were injected into the rat striatum. Protein expression analysis showed that our AAV2 vector efficiently delivered the neurotrophic factor genes into the brain and gave rise to a long-lasting expression of the proteins. Two weeks after AAV2 vector injection, 6-OHDA was injected into the rat striatum, creating a progressive degeneration of the nigrostriatal dopaminergic system. Treatment with AAV2-CDNF resulted in a marked decrease in amphetamine-induced ipsilateral rotations while it provid ed only partial protection of tyrosine hydroxylase (TH)-immunoreactive cells in the rat substantia nigra pars compacta and TH-reactive fibers in the striatum. Results from this study provide additional evidence that CDNF can be considered a potential treatment of Parkinson’s disease

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