OEM Customized Paypal - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM
OEM Customized Paypal - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM Detail:
Catalog Number | XD90307 |
Product Name | L-lysine dihydrochloride |
CAS |
657-26-1 |
Molecular Formula |
C6H14N2O2.2[HCl] |
Molecular Weight |
219.10944 |
Storage Details | Ambient |
Harmonized Tariff Code | 29224100 |
Product Specification
Melting Point | 200 – 205 Deg C |
Water | <0.5% |
Optical Rotation | +15.9 |
Appearance | White crystalline powder |
Assay (Titration ex Chloride) | >99% |
Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of the main symptoms of this genetic disorder is a loss of sub-cutaneous fat due to a dramatic lipodystrophy.We stably induced the expression of human PG and GFP -Green Fluorescent Protein- as control in 3T3L1 cells using a lentiviral system to study the effect of PG expression in the differentiation capacity of this cell line, one of the most used adipogenic models. Quantitative proteomics (iTRAQ) was done to study the effect of the PG accumulation. Several of the modulated proteins were validated by immunoblotting and real-time PCR. Mitochondrial function was analyzed by measurement of a) the mitochondrial basal activity, b) the superoxide anion production and c) the individual efficiency of the different complex of the respiratory chain.We found that over-expression PG by lentivi ral gene delivery leads to a decrease in the proliferation rate and to defects in adipogenic capacity when compared to the control. Quantitative proteomics analysis showed 181 proteins significantly (p<0.05) modulated in PG-expressing preadipocytes. Mitochondrial function is impaired in PG-expressing cells. Specifically, we have detected an increase in the activity of the complex I and an overproduction of Superoxide anion. Incubation with Reactive Oxygen Species (ROS) scavenger agents drives to a decrease in autophagic proteolysis as revealed by LC3-II/LC3-I ratio.PG expression in 3T3L1 cells promotes changes in several Biological Processes, including structure of cytoskeleton, lipid metabolism, calcium regulation, translation, protein folding and energy generation by the mitochondria. Our data strengthen the contribution of ROS accumulation to the premature aging phenotype and establish a link between mitochondrial dysfunction and loss of proteostasis in HGPS.
Product detail pictures:
Related Product Guide:
Sticking for the belief of "Creating items of top of the range and creating buddies with people today from all over the world", we normally put the interest of shoppers in the first place for OEM Customized Paypal - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Sweden, Cape Town, Manchester, Our items have national accreditation requirements for qualified, high quality goods, affordable value, was welcomed by people today all over the world. Our products will continue to enhance within the order and look forward to cooperation with you, Should really any of these products and solutions be of curiosity to you, be sure to letus know. We are likely to be content to offer you a quotation up on receipt of your detailed needs.
By Jocelyn from Bolivia - 2017.11.12 12:31
The supplier cooperation attitude is very good, encountered various problems, always willing to cooperate with us, to us as the real God.
By Mary from Sydney - 2018.12.30 10:21