page_banner

Products

Factory source Pharmaceutical Manager - L-Glutamine Cas: 56-85-9 99% White powder – XD BIOCHEM

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Our pursuit and company goal is to "Always satisfy our customer requirements". We continue to develop and design superior quality products for both our old and new customers and achieve a win-win prospect for our clients as well as us for Tris-Hcl, Pilot Plant And Manufacturing, 604-68-2, First business, we learn each other. Further business, the trust is getting there. Our company always at your service at any time.
Factory source Pharmaceutical Manager - L-Glutamine Cas: 56-85-9 99% White powder – XD BIOCHEM Detail:

Catalog Number XD90309
Product Name L-Glutamine

CAS

56-85-9

Molecular Formula

C5H10N2O3

Molecular Weight

146.1445
Storage Details Ambient
Harmonized Tariff Code 29241900

 

Product Specification

Storage Temperature +20 Deg C
Molecular Weight 146.14
Assay 99.0% min
Appearance White powder

 

1.Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/ETP-ALL. Using a conditional gain-of-function mouse model, we demonstrate that sustained Zeb2 expression initiates T-cell leukaemia. Moreover, Zeb2-driven mouse leukaemia exhibit some features of the human immature/ETP-ALL gene expression signature, as well as an enhanced leukaemia-initiation potential and activated Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signalling through transcriptional activation of IL7R. This study reveals ZEB2 as an oncogene in the biology of immature/ETP-ALL and paves the way towards pre-clinical studies of novel compounds for the treatment of this aggressive subtype of human T-ALL using our Zeb2-driven mouse model.

2.Pluripotency, self-renewal, and differentiation are special features of embryonic stem (ES) cells, thereby providing valuable perspectives in regenerative medicine. Developmental processes require a fine-tuned organization, mainly regulated by the well-known JAK/STAT, PI3K/AKT, and ERK/MAPK pathways. SPREDs (Sprouty related proteins with EVH1 domain) were discovered as inhibitors of the ERK/MAPK signaling pathway, whereas nothing was known about their functions in ES cells and during early differentiation, so far.We generated SPRED1 and SPRED2 overexpressing and SPRED2 knockout murine ES cells to analyze the functions of SPRED proteins in ES cells and during early differentiation. Overexpression of SPREDs increases significantly the self-renewal and clonogenicity of murine ES cells, whereas lack of SPRED2 reduces proliferation and increases apoptosis. During early differentiation in embryoid bodies, SPREDs promote the pluripotent state and inhibit differentiation whereby mesodermal d ifferentiation into cardiomyocytes is considerably delayed and inhibited. LIF- and growth factor-stimulation revealed that SPREDs inhibit ERK/MAPK activation in murine ES cells. However, no effects were detectable on LIF-induced activation of the JAK/STAT3, or PI3K/AKT signaling pathway by SPRED proteins.We show that SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK signaling pathway in pluripotent cells.


Product detail pictures:

Factory source Pharmaceutical Manager - L-Glutamine  Cas: 56-85-9  99%  White powder – XD BIOCHEM detail pictures


Related Product Guide:

To fulfill the customers' over-expected satisfaction , we have now our strong crew to provide our greatest general assistance which incorporates promoting, gross sales, planning, creation, top quality controlling, packing, warehousing and logistics for Factory source Pharmaceutical Manager - L-Glutamine Cas: 56-85-9 99% White powder – XD BIOCHEM , The product will supply to all over the world, such as: Adelaide, Bulgaria, Los Angeles, We are very responsible for all details on our customers order no matter on warranty quality, satisfied prices, quick delivery, on time communication, satisfied packing, easy payment terms, best shipment terms, after sales service etc. We provide one-stop service and best reliability to our every customers. We work hard with our customers, colleagues, workers to make a better future.
  • The company comply with the contract strict, a very reputable manufacturers, worthy a long-term cooperation.
    5 Stars By Eleanore from Armenia - 2018.06.12 16:22
    Products and services are very good, our leader is very satisfied with this procurement, it is better than we expected,
    5 Stars By Audrey from British - 2018.02.04 14:13
    Close

    Factory source Pharmaceutical Manager - L-Glutamine Cas: 56-85-9 99% White powder – XD BIOCHEM