page_banner

Products

Factory source Pharmaceutical Manager - β-Alanine CAS:107-95-9 White crystalline powder – XD BIOCHEM

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Well-run equipment, expert income workforce, and far better after-sales expert services; We are also a unified large family, anyone stick to the corporate value "unification, dedication, tolerance" for Cpt, Bevacizumab, D-(+)-Galactose, Now we have extensive goods source as well as price tag is our advantage. Welcome to inquire about our products and solutions.
Factory source Pharmaceutical Manager - β-Alanine CAS:107-95-9 White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90324
Product Name β-Alanine
CAS 107-95-9
Molecular Formula C3H7NO2
Molecular Weight 89.09
Storage Details Ambient
Harmonized Tariff Code 29224920

 

Product Specification

Appearance White crystalline powder
Assay 99%

 

Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation, ballooning and degradation of hepatocytes, and fibrosis. Ultimately, steatohepatitis can result in liver cirrhosis and hepatocellular carcinoma.In this study we have analyzed three different mouse strains, A/J, C57BL/6J, and PWD/PhJ, that show different degrees of steatohepatitis when administered a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) containing diet. RNA-Seq gene expression analysis, protein analysis and metabolic profiling were applied to identify differentially expressed genes/proteins and perturbed metabolite levels of mouse liver samples upon DDC-treatment. Pathway analysis revealed alteration of arachidonic acid (AA) and S-adenosylmethionine (SAMe) metabolism upon other pathways. To understand metabolic changes of arachidonic aci d metabolism in the light of disease expression profiles a kinetic model of this pathway was developed and optimized according to metabolite levels. Subsequently, the model was used to study in silico effects of potential drug targets for steatohepatitis.We identified AA/eicosanoid metabolism as highly perturbed in DDC-induced mice using a combination of an experimental and in silico approach. Our analysis of the AA/eicosanoid metabolic pathway suggests that 5-hydroxyeicosatetraenoic acid (5-HETE), 15-hydroxyeicosatetraenoic acid (15-HETE) and prostaglandin D2 (PGD2) are perturbed in DDC mice. We further demonstrate that a dynamic model can be used for qualitative prediction of metabolic changes based on transcriptomics data in a disease-related context. Furthermore, SAMe metabolism was identified as being perturbed due to DDC treatment. Several genes as well as some metabolites of this module show differences between A/J and C57BL/6J on the one hand and PWD/PhJ on the other.


Product detail pictures:

Factory source Pharmaceutical Manager - β-Alanine  CAS:107-95-9  White crystalline powder – XD BIOCHEM detail pictures


Related Product Guide:

Well-run equipment, specialist income crew, and better after-sales services; We're also a unified major family, anyone stay with the organization value "unification, determination, tolerance" for Factory source Pharmaceutical Manager - β-Alanine CAS:107-95-9 White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Afghanistan, Uruguay, Seychelles, We've got won a good reputation among overseas and domestic clients. Adhering to the management tenet of "credit oriented, customer first, high efficiency and mature services", we warmly welcome friends from all walks of life to cooperate with us.
  • This supplier's raw material quality is stable and reliable, has always been in accordance with the requirements of our company to provide the goods that quality meet our requirements.
    5 Stars By Nora from belarus - 2017.08.21 14:13
    The factory can meet continuously developing economic and market needs, so that their products are widely recognized and trusted, and that's why we chose this company.
    5 Stars By Marina from Angola - 2017.09.29 11:19
    Close

    Factory source Pharmaceutical Manager - β-Alanine CAS:107-95-9 White crystalline powder – XD BIOCHEM