Factory Outlets Pd-L1 Mab Bavencio - L-Tryptophan Cas: 73-22-3 99% White powder – XD BIOCHEM
Factory Outlets Pd-L1 Mab Bavencio - L-Tryptophan Cas: 73-22-3 99% White powder – XD BIOCHEM Detail:
Catalog Number | XD90295 |
Product Name | L-Tryptophan |
CAS |
73-22-3 |
Molecular Formula |
C11H12N2O2 |
Molecular Weight |
204.22518 |
Storage Details | Ambient |
Harmonized Tariff Code |
29339980 |
Product Specification
Assay | 99%min |
Appearance | White powder |
Grade | USP32 |
Specific rotation | -29.4 to -32.8 |
pH | 5.5 to 7.0 |
Fe | <0.003% |
Pb | <0.0015% |
Loss on Drying | <0.3% |
Residue on Ignition | 0.1%max |
Cl | 0.05%max |
Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 has been clinically validated as a small-molecule drug target for cancer, while preclinical studies indicate that TDO may be a target for cancer immunotherapy and neurodegenerative disease. We have developed a high-throughput screening assay for IDO1 and TDO based on a novel chemical probe, NFK Green, that reacts specifically with NFK to form a green fluorescent molecule with an excitation wavelength of 400 nm and an emission wavelength of 510 nm. We provide the first side-by-side comparison of a number of published inhibitors of IDO1 and TDO and reveal that the preclinical IDO1 inhibitor Compound 5l shows significant cross-reactivity with TDO, while the relative selectivity of other published inhibitors was confirmed. The suitabil ity for high-throughput screening of the assays was demonstrated by screening a library of 87,000 chemical substances in 384- or 1536-well format. Finally, we demonstrate that the assay can also be used to measure the capacity of cells to metabolize tryptophan and to measure the cellular potency of IDO1 and TDO inhibitors.
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Dependable high-quality and fantastic credit standing are our principles, which will help us at a top-ranking position. Adhering to your tenet of "quality very first, client supreme" for Factory Outlets Pd-L1 Mab Bavencio - L-Tryptophan Cas: 73-22-3 99% White powder – XD BIOCHEM , The product will supply to all over the world, such as: Cyprus, Adelaide, Hamburg, We are increasingly expanding our international market share based on quality products, excellent service, reasonable price and timely delivery. Please contact us at any time for more information.
By Eartha from Cyprus - 2017.03.07 13:42
We feel easy to cooperate with this company, the supplier is very responsible, thanks.There will be more in-depth cooperation.
By Modesty from Leicester - 2017.04.08 14:55