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Doxorubicin hydrochloride CAS:25316-40-9 99% Orange-red Crystalline powder

Short Description:

Catalog Number: XD90367
CAS: 25316-40-9
Molecular Formula: C27H29NO11·HCl
Molecular Weight: 579.98
Availability: In Stock
Price:  
Prepack: 25mg USD10
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Product Detail

Product Tags

Catalog Number XD90367
Product Name Doxorubicin hydrochloride
CAS 25316-40-9
Molecular Formula C27H29NO11·HCl
Molecular Weight 579.98
Storage Details 2 to 8 °C
Harmonized Tariff Code 29419000

 

Product Specification

Water Content ≤ 4.0%
pH 4.0-5.5
Solubility Soluble in: water, methanol and isotonic NaCl(aq). Poor solubility in chloroform and other organic solvents.
Related Substances Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5%
Assay 99%
Residual Solvents Acetone and alcohol: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm
Any Other Impurities ≤ 0.5%
Total Impurities ≤ 2.0%
Crystallinity Complies with USP
Appearance Orange-red Crystalline powder
Identification HPLC

 

Patients with P-glycoprotein and HER2/neu (HER2) receptor-overexpressing breast cancer usually have poor clinical outcomes. However, there exist no commercially available breast cancer cell lines that are HER2/P-glycoprotein double-positive, which limits research in this field.We report on the development and characterization of a drug-resistant sub-line from an HER2-positive breast cancer cell line by stable transfection of the ATP-binding cassette (ABC) subfamily B member 1 (ABCB1) gene which encodes P-glycoprotein.ABCB1 gene expression levels were higher after transfection, which led to a 40-fold increase in P-glycoprotein expression. Interestingly, the transfection of ABCB1 also led to a slight increase in HER2 gene and protein expression levels. The transfection of ABCB1 increased the P-glycoprotein expression levels significantly.The method used herein for developing this cell line is appropriate for fast, stable induction of P-glycoprotein-mediated drug resistance compared to tr aditional methods. The in vitro cytotoxicity test suggests this cell line has cross-resistance to a wide range of chemotherapeutic agents.


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    Doxorubicin hydrochloride CAS:25316-40-9 99% Orange-red Crystalline powder