18 Years Factory Tris(Hydroxymethyl)Nitromethane - 5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder – XD BIOCHEM
18 Years Factory Tris(Hydroxymethyl)Nitromethane - 5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder – XD BIOCHEM Detail:
Catalog Number | XD90224 |
Product Name | 5-Methylphenazinium methosulfate |
CAS |
299-11-6 |
Molecular Formula |
C14H14N2O4S |
Molecular Weight |
306.337 |
Storage Details | -15 to -20 °C |
Harmonized Tariff Code | 29339980 |
Product Specification
Melting Point | 158-160 °C (dec.)(lit.) |
Assay | 99% |
Form | Solid |
Appearance | Dark green to brown powder |
The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients and to induce apoptotic tumor cell death in vitro. Until now, EPA and DHA have never been investigated in multiple myeloma (MM). Human myeloma cells (L363, OPM-1, OPM-2 and U266) and normal peripheral blood mononuclear cells were exposed to EPA and DHA, and effects on mitochondrial function and apoptosis, caspase-3 activation, gene expression and drug toxicity were measured. Exposure to EPA and DHA induced apoptosis and increased sensitivity to bortezomib in MM cells. Importantly, they did not affect viability of normal human peripheral mononuclear cells. Messenger RNA expression arrays showed that EPA and DHA modulated genes involved in multiple signaling pathways including nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress and Wnt. EPA and DHA inhibited NFκB activity and induced apo ptosis through mitochondrial perturbation and caspase-3 activation. Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM
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"Sincerity, Innovation, Rigorousness, and Efficiency" could be the persistent conception of our enterprise to the long-term to produce together with clients for mutual reciprocity and mutual profit for 18 Years Factory Tris(Hydroxymethyl)Nitromethane - 5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder – XD BIOCHEM , The product will supply to all over the world, such as: Pakistan, Brasilia, Malta, To achieve reciprocal advantages, our company is widely boosting our tactics of globalization in terms of communication with overseas customers, fast delivery, the best quality and long-term cooperation. Our company upholds the spirit of "innovation, harmony, team work and sharing, trails, pragmatic progress". Give us a chance and we'll prove our capability. With your kind help, we believe that we can create a bright future with you together.
By Erin from Philadelphia - 2017.08.21 14:13
The product manager is a very hot and professional person, we have a pleasant conversation, and finally we reached a consensus agreement.
By Ophelia from Madras - 2018.06.09 12:42